Hormonal
Treating 50% of moderate- to high-risk obesity patients (Class II and III, excluding diabetes) with 2.4 mg weekly semaglutide plus lifestyle intervention for 68 weeks reduces population prevalence of these obesity classes and yields significant annual societal cost savings.
For healthcare policymakers and insurers, implementing widespread access to 2.4 mg weekly semaglutide for moderate-to-high risk obesity (excluding diabetics) alongside lifestyle programs can significantly reduce the prevalence of severe obesity and save billions in societal costs over time. This requires ensuring affordability and addressing long-term adherence.
Treating 50% of patients with obesity class II and III (excl. diabetes patients, including patients not responding to the treatment) over 68 weeks, reduced the prevalence from 4% to 2.74%... and from 1.45% to 0.97%... This resulted in a reduction of 12.9% (€ − 108.7 million) of expenses related to obesity class II and III per year.
Why this rating
Based on a life-cycle model using data from a clinical trial (Wilding et al.) and population surveys; not a primary RCT itself.
Source
Effects from treating moderate- to high-risk obesity patients with anti-obesity medication from a societal perspective
Stephanie Reitzinger et al. · Scientific Reports · 2025
DOI 10.1038/s41598-025-97472-8
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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