Research
Hormonal
Semaglutide and liraglutide have similar anti-hyperglycemic efficacy, with no consistent significant difference in HbA1c reduction between the two drugs.
For patients with type 2 diabetes, choosing between semaglutide and liraglutide should likely be based on weight loss goals and injection frequency preference, as both drugs lower blood sugar similarly.
ModerateQualifiesMEDIUM confidence
In general, the anti-hyperglycemic efficacy and safety profile are similar in both drugs.
Why this rating
Based on indirect comparisons and mixed head-to-head results.
Source
Semaglutide versus liraglutide for treatment of obesity
Nasser Mikhail · 2021
DOI 10.32474/ado.2021.03.000162
narrative_reviewCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Both semaglutide and liraglutide cause gastrointestinal adverse effects (nausea, vomiting, diarrhea) which are the most common reason for drug discontinuation.Good
- Once-weekly semaglutide 2.4 mg produces significantly greater weight loss than once-daily liraglutide 3.0 mg in patients with obesity, based on indirect comparisons of randomized controlled trials.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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