Hormonal
Inpatient administration of GLP-1 receptor agonists (liraglutide and semaglutide) combined with a very low-calorie diet (800 kcal/day) produces rapid, substantial weight loss (25% of baseline) in severely obese patients (BMI > 100 kg/m2) who are hospitalized.
For severely obese patients (BMI > 100) who struggle with discharge or outpatient adherence, inpatient GLP-1RA therapy combined with a strict 800 kcal/day diet can produce rapid, substantial weight loss (approx. 25% in <8 months). This approach may serve as a bridge to bariatric surgery or functional independence when standard outpatient care fails due to socioeconomic or medical barriers.
The patient lost a total of 174 lbs (79 kg) from the start of the GLP-1RA therapy until week 31... The patient’s weight decreased by 174 lbs (79 kg), or 25% of baseline weight, and BMI decreased from 108 to 81 kg/m2.
Why this rating
This is a single case report (n=1), which provides low generalizability despite the dramatic result.
Source
Weight Loss Effects of Glucagon-Like Peptide-One Receptor Analog Treatment in a Severely Obese Patient During Hospital Admission
Yaiseli Figueredo et al. · Cureus · 2023
DOI 10.7759/cureus.34331
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