Hormonal
Discontinuation of semaglutide or tirzepatide prior to pregnancy leads to expected weight regain, which may cause fetal macrosomia and negate the metabolic benefits of prior weight loss.
If you are using semaglutide or tirzepatide and planning pregnancy, you must stop the medication 1-2 months before trying to conceive. Be aware that you will likely regain some weight during this time, which can increase the risk of the baby being too large (macrosomia). To minimize this, focus on strength training and high-protein nutrition immediately after stopping the drug.
Discontinuation of these medications is necessary prior to pregnancy but comes with the expectation of weight regain... 'Excess' weight regain in early pregnancy post-GLP-1 RA discontinuation has been described in a case report in which the authors proposed that the weight rebound after recent medication use was a potential contributor to observed fetal macrosomia.
Why this rating
Based on large clinical trials (STEP/SURMOUNT) showing regain, but human pregnancy data is limited to case reports and reviews.
Source
Consideration of Use of Semaglutide and Tirzepatide Prior to Pregnancy
Alyse S. Goldberg · Canadian Women s Health Today · 2024
DOI 10.58931/cwht.2024.1210
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