Research
Hormonal
GLP-1 receptor agonists (semaglutide, tirzepatide) produce superior weight loss (>10% initial body weight) compared to other approved anti-obesity medications by acting centrally to increase satiety and reduce appetite.
If lifestyle changes alone haven't worked, GLP-1 agonists like semaglutide or tirzepatide are the most effective pharmacological options, capable of producing over 10% weight loss. These require weekly injections and a gradual dose titration to manage side effects like nausea.
StrongSupportsHIGH confidence
The most effective anti-obesity drugs are semaglutide and tirzepatide, which might provide weight loss of more than 10% of the initial weight. Most of them, except orlistat, predominantly act centrally by increasing satiety, as well as reducing appetite and food reward.
Why this rating
Based on large-scale clinical trials (e.g., Jastreboff et al., 2022) cited in the paper.
Source
Pharmacotherapy of obesity: State of the art and perspectives
Katarina Sićović et al. · Arhiv za farmaciju · 2024
narrative_reviewCited 1×
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