Hormonal
A history of metabolic surgery (specifically sleeve gastrectomy) significantly attenuates the weight-loss efficacy of liraglutide in patients with mild obesity, resulting in substantially lower total weight loss compared to non-surgical patients.
If you have had weight-loss surgery (especially sleeve gastrectomy), standard doses of liraglutide may not work as well as they do for others. Your doctor might need to increase your dose to 3.0 mg (if approved/available) or switch you to a different medication like tirzepatide to achieve similar weight loss results. Do not assume the standard dose will be sufficient.
Regression analysis identified a history metabolic surgery (MS) and a baseline BMI ≥30.5 kg/m² as significant negative predictors of success... patients with a history of MS and a baseline BMI >30.5 kg/m² were significantly less likely to achieve treatment targets... Patients without MS had a greater % TWL compared to those who were post-MS (9.6 ± 0.7% vs 5.2 ± 0.8%, P<.01)
Why this rating
Retrospective cohort study with a small sample size (n=64) and single-center design, limiting generalizability.
Source
Prior metabolic surgery attenuates the weight-loss efficacy of liraglutide in patients with mild obesity
Yuqin Ouyang et al. · Frontiers in Endocrinology · 2025
DOI 10.3389/fendo.2025.1580159
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