Hormonal
Tirzepatide (5, 10, and 15 mg) is a cost-effective treatment for weight management compared to liraglutide in the UK, demonstrating dominance (cost savings and QALY gains) in the general obesity trial population and favorable ICERs in the specific NICE-reimbursed population.
For patients in the UK with obesity or overweight plus complications, tirzepatide (5, 10, or 15 mg weekly) combined with diet and exercise is a cost-effective treatment option compared to liraglutide. It offers potential cost savings and quality-of-life gains, and unlike liraglutide which is restricted to specialist services, tirzepatide can be prescribed in primary care.
In the trial population, all doses of tirzepatide were dominant to liraglutide, with estimated cost savings and QALY gains. In liraglutide’s UK recommended population the estimated ICERs for tirzepatide vs liraglutide were £5401–7864/QALY gained across doses
Why this rating
Based on a simulation model informed by network meta-analysis and trial data, not a direct head-to-head RCT.
Source
Cost-Effectiveness of Tirzepatide Versus Liraglutide, Both Adjunct to Diet and Exercise, for Patients with Obesity or Overweight: A UK Perspective
Matthew Capehorn et al. · Advances in Therapy · 2025
DOI 10.1007/s12325-025-03288-3
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