Hormonal
Discontinuation of obesity management medications (OMMs) such as tirzepatide or semaglutide leads to substantial weight regain and partial reversal of cardiometabolic improvements, indicating that sustained treatment is required to maintain health benefits.
If you stop taking your obesity medication (like tirzepatide or semaglutide), you will likely regain most of the weight you lost, even if you keep your diet and exercise habits. To keep the health benefits, you generally need to stay on the medication long-term.
the cardiometabolic risk factor benefits achieved with body weight reduction during OMM treatment have been shown to deteriorate with the rapid weight regain, also known as weight recurrence, that occurs from OMM discontinuation... 1 year after discontinuation of semaglutide and the lifestyle intervention program, participants had regained two-thirds of their prior weight reduction and partial reversal of improvements in cardiometabolic metrics
Why this rating
Based on cited Phase 3 trials (SURMOUNT-4, STEP 4, STEP 1 extension) which are robust clinical studies, though this specific paper is a design/baseline report.
Source
Tirzepatide for the Maintenance of Body Weight Reduction: Rationale, Design, and Baseline Characteristics of <scp>SURMOUNT</scp>‐<scp>MAINTAIN</scp>
Deborah B. Horn et al. · Obesity · 2025
DOI 10.1002/oby.70014
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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