Research
Hormonal
Tirzepatide use is associated with specific adverse events in males, including sleep disorders, delayed gastric emptying, and medullary thyroid cancer.
Men taking tirzepatide should be aware of potential sleep issues and digestive delays. Those with a family history of thyroid cancer should discuss the risks with their doctor before starting treatment.
ModerateSupportsMEDIUM confidence
Sleep disorder, delayed gastric emptying, and medullary thyroid cancer are more common in males.
Why this rating
Based on FAERS data; strong signal for thyroid cancer given its known risk, but spontaneous reporting limits causal certainty.
Source
Adverse Events Associated with Tirzepatide: Updated Pharmacovigilance Analysis Using FAERS (2022 Q1-2025 Q1) with an Adapted Time-to-Onset Method
Saisai Gu · Drug Healthcare and Patient Safety · 2026
DOI 10.2147/dhps.s556918
cohort · n=67305Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide use is associated with a high frequency of early-onset adverse events, with a median time-to-onset of approximately 6.4 days, driven by gastrointestinal disturbances, injection site reactions, and metabolic effects.Moderate
- Tirzepatide use is associated with specific adverse events in females, including starvation ketoacidosis, menstrual disorders, and postmenopausal hemorrhage.Moderate
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