Research

Hormonal

Long-acting GLP-1 receptor agonists (semaglutide and dulaglutide) provide superior efficacy, particularly in cardio-renal protection, and overall value compared to other long-acting GLP-1RAs in China, earning strong clinical recommendations.

For patients with Type 2 Diabetes in China, Semaglutide and Dulaglutide are the preferred long-acting GLP-1 receptor agonists. They offer strong recommendations due to superior efficacy, particularly in protecting the heart and kidneys, and better overall value. While newer drugs like Tirzepatide show great potential for weight loss and glucose control, their high cost and lack of insurance coverage make them less accessible. Patients should discuss these options with their doctors, prioritizing agents with established cardiovascular benefits and insurance coverage.

GoodSupportsHIGH confidence
Semaglutide and dulaglutide, classified as Strong Recommendations, demonstrated superior efficacy (particularly in cardio-renal protection) and overall value.
Qiying Chen et al. · Diabetes Metabolic Syndrome and Obesity · 2026

Why this rating

Based on a systematic multi-dimensional evaluation using Delphi expert consultation, drug labels, systematic literature review, and real-world data.

Source

A Clinical Comprehensive Evaluation of Long-Acting GLP-1 Receptor Agonists in Type 2 Diabetes Management

Qiying Chen et al. · Diabetes Metabolic Syndrome and Obesity · 2026

DOI 10.2147/dmso.s585436

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DOI resolved against Crossref · corpus check 2026-06-10

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