Hormonal
Treatment with tirzepatide (10-15 mg weekly) causes significant shifts to lower BMI categories in adults with obesity, which is associated with substantial improvements in cardiometabolic risk factors including blood pressure, fasting insulin, and lipid profiles.
If you have obesity or overweight with related health issues like high blood pressure or high cholesterol, talk to your doctor about tirzepatide. It is a once-weekly injection that helps many people move to a lower BMI category, which is linked to better heart health and metabolic markers. It works best when combined with a reduced-calorie diet and increased physical activity.
In these post hoc analyses, the majority of tirzepatide-treated participants with obesity or overweight shifted to lower BMI categories. Tirzepatide treatment was associated with significantly improved cardiometabolic risk factors in participants who shifted to a lower BMI category, which may positively impact long-term cardiovascular outcomes.
Why this rating
Post hoc analysis of two large, randomized, controlled phase 3 trials (SURMOUNT-1 and SURMOUNT-4).
Source
Shifts in body mass index category with tirzepatide and associated changes in cardiometabolic risk factors in people with obesity: a post hoc analysis from the SURMOUNT-1 and SURMOUNT-4 trials
Naveed Sattar et al. · American Journal of Preventive Cardiology · 2026
DOI 10.1016/j.ajpc.2026.101454
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