Hormonal
GLP-1 receptor agonists (GLP-1 RAs) including semaglutide, tirzepatide, and liraglutide produce significant weight loss in adults with obesity, with efficacy increasing with higher doses and outperforming placebo.
GLP-1 medications like semaglutide and tirzepatide are highly effective for weight loss, often producing 15-20% body weight reduction in clinical trials. They work by mimicking natural hormones to reduce appetite and slow digestion. While effective, they can cause gastrointestinal side effects like nausea, which are usually manageable and temporary. Consult a doctor to determine if this treatment is appropriate for your specific health profile.
Participants administered 5 mg, 10 mg, and 15 mg of tirzepatide achieved mean weight losses of 15.0%, 19.5%, and 20.9%, respectively, while the placebo group had a mean weight loss of only 3.1%.
Why this rating
Based on multiple large-scale, randomized, double-blind clinical trials (e.g., SELECT, phase 3 tirzepatide study).
Source
Glucagon-Like Peptide-1 Receptor Agonist Mediated Weight Loss and Diabetes Mellitus Benefits: A Narrative Review
Alan D. Kaye et al. · Cureus · 2024
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