Hormonal
Semaglutide (2.4 mg weekly) combined with intensive behavioral therapy produces significantly greater weight loss (16.0%) and cardiometabolic improvements compared to behavioral therapy alone (5.7%).
If you have obesity or overweight with related health issues, combining a weekly semaglutide injection (titrated to 2.4 mg) with intensive lifestyle changes (diet, exercise, counseling) can lead to substantial weight loss (around 16%) and better heart health markers compared to lifestyle changes alone. Be aware that stopping the drug may lead to weight regain, so it is intended for long-term management.
In a randomized controlled trial (RCT) of participants undergoing intensive behavioural therapy... those who also received semaglutide (2.4 mg) lost an average of 16.0% of their baseline weight, compared with 5.7% among those who received placebo. Participants who received semaglutide had improvements in diastolic blood pressure, lipid profiles and glycated hemoglobin levels.
Why this rating
Based on a cited Randomized Controlled Trial (STEP 3) comparing drug to placebo with behavioral therapy.
Source
Novel obesity treatments
Shohinee Sarma et al. · Canadian Medical Association Journal · 2023
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