Hormonal
Tirzepatide (0.144 mg/kg) significantly reduces voluntary alcohol consumption, prevents binge-like drinking, and suppresses relapse-like behaviors in rodents.
Tirzepatide, a dual GLP-1/GIP agonist, significantly reduces alcohol consumption and prevents relapse in rodent models by attenuating dopamine reward signaling. While preclinical, these findings suggest potential for treating Alcohol Use Disorder (AUD) and its metabolic complications.
Tirzepatide dose-dependently reduced voluntary alcohol consumption, prevented binge and relapse-like drinking, and maintained efficacy during repeated administration.
Why this rating
Strong preclinical evidence across multiple models and sexes, but not yet human clinical trials.
Source
Tirzepatide attenuates dopamine reward signaling and suppresses alcohol drinking and relapse-like behaviors in rodents
Christian E. Edvardsson et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2025
DOI 10.1101/2025.08.26.672374
More from this paper
- Tirzepatide attenuates alcohol-induced dopamine release in the nucleus accumbens and induces sustained synaptic depression in the lateral septum.Good
- Tirzepatide improves metabolic and inflammatory markers in alcohol-consuming rodents, including reducing body weight, white adipose tissue, hepatic triglycerides, and pro-inflammatory cytokines.Good
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