Hormonal
Coleus forskohlii (Forskolin) supplementation reduces body fat, increases lean mass, and improves insulin sensitivity in overweight/obese men.
Coleus forskohlii (Forskolin) taken daily for 12 weeks may help reduce body fat and increase lean mass in overweight men, improving insulin sensitivity. It works by increasing cAMP, which stimulates fat breakdown.
In a study on overweight men, the forskolin supplementation group for 12 weeks showed significant fat loss, increased lean body mass, increased basal metabolic rate, and improved insulin sensitivity compared to the placebo group.
Why this rating
The paper cites a specific RCT (Godard et al., 2005) but notes that long-term safety and efficacy need further study.
Source
Literature Review on the Effects of Functional Food Ingredients for Blood Glucose and Body Fat Reduction on Glycemic Control in Insulin Resistance and Diabetes
Nohyeon Kim et al. · Journal of the Korean Society of Food Science and Nutrition · 2025
DOI 10.3746/jkfn.2025.54.10.805
More from this paper
- Visceral adipose tissue (VAT) accumulation exacerbates insulin resistance and increases fasting blood glucose and HbA1c, whereas brown adipose tissue (BAT) activation improves glucose regulation and insulin sensitivity.Good
- Garcinia cambogia (Hydroxycitric acid/HCA) supplementation reduces visceral fat and improves fasting blood glucose and insulin sensitivity in overweight/obese individuals.Moderate
- Banaba leaf extract (Corosolic acid) and Resistant Maltodextrin (RMD) improve blood glucose control and insulin sensitivity through distinct mechanisms.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →