Hormonal
Carriers of the TCF7L2 rs7903146 T allele exhibit significantly attenuated weight loss and metabolic improvements compared to non-T allele (CC) carriers when following a partial meal replacement (pMR) hypocaloric diet.
If you have the TCF7L2 rs7903146 T allele, expect your weight loss to be roughly half as fast as someone with the CC genotype on a similar meal-replacement diet. Focus on metabolic health markers (blood sugar, insulin) as early wins, as these improve significantly even if the scale moves slower.
The decrease at 24 weeks was higher in non-T allele carriers compared to T allele carriers (BMI: -3.3±0.3 kg/m² vs. -2.2±0.2 kg/m², p=0.02; weight: -9.5±1.1 kg vs. -5.0±1.0 kg, p=0.01... glucose levels: -7.1±1.2 mg/dL vs. -1.2±1.1 mg/dL, p=0.01... HOMA-IR: -2.1±1.1 units vs. -0.5±0.1 units, p=0.01).
Why this rating
Single-center interventional study with a moderate sample size (n=214) and no control group, but with rigorous genotyping and biochemical analysis.
Source
Effect of the Variant rs7903146 of Transcription Factor 7-Like 2 Gene on Anthropometric and Metabolic Responses to a 24 Weeks Meal Replacement Hypocaloric Diet
Daniel Antonio de Luis et al. · Annals of Nutrition and Metabolism · 2025
DOI 10.1159/000543557
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