Macro partitioning
Higher intake of Polyunsaturated Fatty Acids (PUFAs) is associated with a reduced risk of overall mortality, whereas Saturated Fatty Acid (SFA) intake is positively associated with increased mortality risk.
Increase your intake of Polyunsaturated Fats (PUFAs) by eating more fatty fish (like salmon, mackerel), walnuts, and seeds. Simultaneously, reduce your intake of Saturated Fats (SFAs) found in red meat and full-fat dairy. This shift is associated with a lower risk of death.
The intake of SFAs was positively associated with an increased risk of overall mortality... whereas an inverse association of PUFAs intake with overall mortality was observed
Why this rating
Large cohort, robust statistical adjustment, consistent with other major cohort studies, though observational.
Source
The association of dietary fatty acids intake with overall and cause-specific mortality: a prospective cohort study from 1999–2018 cycles of the NHANES
Zhaoxiang Zhang et al. · Frontiers in Nutrition · 2025
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