Macro partitioning

Following a 2-week adaptation to ad libitum low-carbohydrate or low-fat diets, consuming an isocaloric meal matching the prior diet's macronutrient profile results in significantly lower postprandial glucose, insulin, and triglycerides on a low-carbohydrate diet compared to a low-fat diet.

If you switch to a low-carb diet for two weeks, your body adapts. When you then eat a meal matching that low-carb style, your blood sugar and insulin spikes are significantly lower than if you had been eating a low-fat diet. This suggests that dietary adaptation to macronutrient composition significantly influences metabolic health markers.