Macro partitioning
Following a 2-week adaptation to ad libitum low-carbohydrate or low-fat diets, consuming an isocaloric meal matching the prior diet's macronutrient profile results in significantly lower postprandial glucose, insulin, and triglycerides on a low-carbohydrate diet compared to a low-fat diet.
If you switch to a low-carb diet for two weeks, your body adapts. When you then eat a meal matching that low-carb style, your blood sugar and insulin spikes are significantly lower than if you had been eating a low-fat diet. This suggests that dietary adaptation to macronutrient composition significantly influences metabolic health markers.
Average postprandial levels of glucose, lactate, insulin, and c-peptide were significantly lower following the LC meal... whereas free fatty acids and triglycerides were significantly higher... compared to the LF meal.
Why this rating
Randomized crossover design in a controlled inpatient setting with healthy volunteers, though sample size is small (n=16) and duration is short (2 weeks).
Source
Postprandial Responses to Isocaloric Low-Carbohydrate vs Low-Fat Meals After 2 Weeks of Inpatient Ad libitum Feeding
Lauren Milley et al. · Current Developments in Nutrition · 2020
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