Hormonal
GLP-1 agonists (semaglutide 2.4 mg SC weekly and tirzepatide 5-15 mg SC weekly) produce profound weight loss (15-21% body weight reduction) in overweight/obese adults, significantly outperforming placebo and existing pharmacologic strategies like metformin.
If you are struggling with significant weight gain, particularly from psychiatric medications, GLP-1 agonists like semaglutide or tirzepatide offer the most effective pharmacological solution currently available, capable of producing 15-20% body weight loss. These require weekly injections and lifestyle changes, and while they cause transient gastrointestinal side effects, their efficacy far exceeds older options like metformin. Consult your provider to see if you qualify based on BMI and medical history.
The use of a relatively new class of incretin mimetics called glucagon-like peptide 1 (GLP-1) agonists... has been associated with profound and often dramatic weight loss and improvement of glycemic parameters in patients with obesity and glycemic dysregulation.
Why this rating
Based on multiple randomized controlled trials (RCTs) and meta-analyses cited (Wilding et al., Jastreboff et al.), though the paper itself is a review.
Source
GLP -1 agonists for weight loss: What you need to know
Joseph F. Goldberg · Current Psychiatry · 2023
DOI 10.12788/cp.0318
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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