Hormonal
Long-acting GLP-1 receptor agonists (specifically Semaglutide 2.4 mg) and dual GIP/GLP-1 co-agonists (specifically Tirzepatide) produce clinically significant weight loss (12-18% average) in adults with obesity, significantly outperforming previous pharmacotherapies and rivaling bariatric surgery.
If you have obesity, older weight-loss drugs often fail to produce lasting results. Newer injectable medications like Semaglutide (Wegovy) and Tirzepatide (Mounjaro) work by mimicking gut hormones to reduce appetite and improve metabolism. In clinical trials, these drugs helped patients lose 12-18% of their body weight on average, with many losing over 20%. This level of weight loss is comparable to bariatric surgery. However, these are prescription medications with potential side effects like nausea, and they require weekly administration. Consult a doctor to see if you are a candidate.
Patients receiving long-acting glucagon-like peptide 1 (GLP1) agonist semaglutide achieve weight loss above 10 %. With tirzepatide, a co-agonist for GLP-1 and the gastric inhibitory polypeptide (GIP) receptor, more than 50 % of the patients even lose above 20 %, which rivals the efficacy of surgical interventions.
Why this rating
Based on Phase 3 clinical trials (STEP, SURPASS, SURMOUNT) cited in the text.
Source
GLP-1-Mimetika — wegweisend zur Behandlung von Diabetes und Adipositas
Kerstin Stemmer et al. · BIOspektrum · 2023
DOI 10.1007/s12268-023-1919-6
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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