Hormonal
Tirzepatide's GIP receptor agonism directly enhances adipocyte glucose uptake and lipid clearance in the fed state by cooperating with insulin, contributing to reduced serum triglycerides without increasing adiposity.
Tirzepatide works partly by helping your fat cells clear sugar and fat from your blood more effectively when you eat, thanks to its GIP receptor activity. This helps lower blood fat levels without making you gain more body fat, complementing the weight loss driven by other mechanisms.
Our findings support a model for long-acting GIPR agonists to modulate both fasted and fed adipose tissue function differentially by cooperating with insulin to augment glucose and lipid clearance in the fed state while enhancing lipid release when insulin levels are reduced in the fasted state.
Why this rating
Strong preclinical evidence using human adipocytes, mouse models, and rodent clamps, though human clinical outcome data is referenced rather than primary.
Source
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor
Ajit Regmi et al. · Cell Metabolism · 2024
DOI 10.1016/j.cmet.2024.05.010
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