Research
Hormonal
Both combined exercise/weight loss and exercise alone reduce low-grade inflammation (CRP) in CAD patients, but only the combined intervention significantly reduces TNFα and suPAR.
While exercise alone reduces general inflammation (CRP), adding weight loss to the regimen further reduces specific inflammatory markers (TNFα, suPAR) associated with plaque instability.
GoodQualifiesHIGH confidence
After 1 year the AIT group obtained a significant 35% (p = 0.019) decrease in CRP while TNFα and suPAR remained unchanged. Intention-to-treat analyses showed a significant decrease following LED + AIT in TNFα, suPAR and CRP...
Why this rating
RCT with clear measurement of inflammatory markers.
Source
Effects of 1 year of exercise training versus combined exercise training and weight loss on body composition, low-grade inflammation and lipids in overweight patients with coronary artery disease: a randomized trial
Lene Rørholm Pedersen et al. · Cardiovascular Diabetology · 2019
DOI 10.1186/s12933-019-0934-x
rct · n=70Cited 95×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Combined aerobic interval training (AIT) and weight loss via low-energy diet (LED) produces superior body composition improvements (weight, fat mass, waist circumference) compared to AIT alone in overweight CAD patients, while both interventions yield similar improvements in VO2peak and lipid profiles.Good
- Combined exercise and weight loss induces a favorable shift in HDL particle size (increase in large HDL2a and HDL2b subclasses) compared to exercise alone, which does not alter HDL distribution.Good
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