Hormonal
Administration of the chimeric multi-agonist peptide GEP44 reduces body weight and energy intake in diet-induced obese mice primarily through a GLP-1 receptor (GLP-1R) dependent mechanism.
This research indicates that a new peptide drug called GEP44 can help reduce body weight and food intake in obese mice by targeting specific receptors in the brain. The effects rely heavily on the GLP-1 receptor, similar to drugs like Ozempic or Wegovy, but GEP44 also targets other receptors (Y1 and Y2). While promising in mice, this is preprint research and not yet available for human use.
These findings support the hypothesis that the chimeric peptide, GEP44, reduces energy intake, BW, core temperature, and glucose levels in male and female DIO mice primarily through a GLP-1R dependent mechanism.
Why this rating
The study is a preprint published on bioRxiv and has not been certified by peer review.
Source
The Novel Chimeric Multi-Agonist Peptide (GEP44) Reduces Energy Intake and Body Weight in Male and Female Diet-Induced Obese Mice in a Glucagon-Like Peptide-1 Receptor-Dependent Manner
James E. Blevins et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2024
DOI 10.1101/2024.05.17.594690
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