Hormonal
Maintaining weight loss is significantly harder than losing it due to physiological mechanisms (AgRP neuron activation, leptin resistance) that drive weight regain, requiring sustained energy deficit and often pharmacological support.
Expect your body to fight back after you lose weight. Biological mechanisms like increased hunger signals (AgRP neurons) will try to restore your previous weight. To counter this, you need a sustained energy deficit, possibly aided by medication, and consistent lifestyle habits. Maintenance is a biological battle, not just a mental one.
Previous experiences in the treatment of obesity have shown that it is incomparably easier to reduce excess body weight than to maintain an achieved lower weight and prevent weight regain... The major challenge in obesity management is weight maintenance after successful weight loss, when the mechanisms by which the body tends to restore the lost energy reserve are activated.
Why this rating
Supported by references to the National Weight Control Registry and physiological studies on AgRP neurons.
Source
Obesity management: A clinician's perspective lečenje gojaznosti iz perspective kliničara
Snežana Polovina et al. · Arhiv za farmaciju · 2024
DOI 10.5937/arhfarm74-50566
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