Research
Hormonal
GLP-1 receptor agonists provide cardiovascular benefits for patients with obesity, even those without diabetes, by reducing the risk of major adverse cardiovascular events.
GLP-1 medications like Semaglutide (2.4 mg weekly) have been shown to reduce the risk of heart attacks, strokes, and cardiovascular death in people with obesity, even if they don't have diabetes. This is a significant benefit beyond weight loss. However, these drugs are expensive and require long-term use.
StrongSupportsVERY_HIGH confidence
结果显示，每周注射一次2.4 mg司美格鲁肽可使成年超重或肥胖人群的主要不良心血管事件(心血管死亡、非致死性心肌梗死，非致死性卒中)风险降低20%。
Why this rating
Based on the SELECT study, a large, randomized, double-blind, placebo-controlled trial.
Source
The glucagon-like peptide-1 (GLP-1) drugs poised to conquer obesity
Jun Yin et al. · Chinese Science Bulletin (Chinese Version) · 2024
DOI 10.1360/tb-2024-0417
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- GLP-1 receptor agonists (GLP-1RAs) induce significant weight loss in adults with obesity or overweight by acting on the central nervous system to increase satiety and on the gastrointestinal tract to delay gastric emptying.Strong
- Multi-receptor agonists (e.g., Tirzepatide, Retatrutide) achieve greater weight loss than single-target GLP-1RAs by simultaneously activating multiple gut hormone receptors (GLP-1R, GIPR, GCGR).Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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