Research
Hormonal
Semaglutide (≥0.2 mg once weekly) demonstrates statistically significant weight loss compared to liraglutide 3.0 mg in patients with obesity without diabetes.
For obese adults without diabetes, semaglutide doses of 0.2 mg or higher (weekly) result in greater weight loss than liraglutide 3.0 mg (daily).
GoodSupportsHIGH confidence
Doses greater than or equal to 0.2 mg semaglutide demonstrated statistically significant weight loss relative to liraglutide.
Why this rating
Based on RCTs included in the review.
Source
Major clinical outcomes of the action of the co-agonist tirzepatide to liraglutide and semaglutide in the treatment of obesity and type 2 diabetes mellitus: a systematic review
Helena Ramalho Arvate · International Journal of Nutrology · 2025
DOI 10.54448/ijn25102
systematic_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Tirzepatide (5-15 mg once weekly) produces superior weight loss (16.5% to 22.4%) and glycemic control compared to GLP-1 monotherapies (liraglutide, semaglutide) and other glucose-lowering medications in patients with type 2 diabetes and obesity.Good
- Liraglutide (3.0 mg once daily) combined with lifestyle changes is an effective treatment for obesity in patients with and without type 2 diabetes, resulting in significant weight loss and maintenance.Good
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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