Research
Hormonal
Discontinuation of GLP-1/GIP agonist therapy leads to significant weight regain, indicating that obesity requires chronic pharmacological management rather than short-term courses.
If you stop taking these medications, you will likely regain the weight. Treat obesity like hypertension: it requires ongoing management. Do not stop without consulting your doctor.
StrongSupportsVERY_HIGH confidence
SURMOUNT-4 study... continued treatment group showed additional 1.9% weight loss, while placebo switch group regained 14.0% of weight.
Why this rating
Based on SURMOUNT-4 RCT.
Source
Recent advances in the pharmacological treatment of obesity
Ga Eun Nam · Journal of Korean Medical Association · 2025
narrative_review
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →