Research
Hormonal
Tirzepatide, a dual GLP-1 and GIP receptor agonist, produces superior total body weight loss (up to 20.9% at 72 weeks) compared to placebo and other anti-obesity medications.
Tirzepatide is a highly effective weekly injection for obesity, achieving nearly 21% weight loss in clinical trials. It works by mimicking hormones that regulate hunger and digestion. While effective, it requires weekly injections and can cause gastrointestinal side effects like nausea.
StrongSupportsHIGH confidence
SURMOUNT-1 (72 weeks): 15 mg: 20.9% weight loss vs 3.1% with placebo
Why this rating
Supported by Phase 3 trials (SURMOUNT-1).
Source
Pharmacotherapy for Obesity: Recent Updates
Thomas W. Fredrick et al. · Clinical Pharmacology Advances and Applications · 2025
narrative_review
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