Research
Hormonal
Leptin resistance is a common trait in obesity that impairs the feedback between fat mass and the hypothalamus, leading to dysregulated appetite and energy storage.
In obesity, the hormone leptin, which signals satiety, often stops working effectively (leptin resistance). This means the brain doesn't receive the 'stop eating' signal even when fat stores are high, contributing to continued overeating.
GoodSupportsHIGH confidence
Leptin resistance, which is a common trait in obesity, likely impairs the feedback between fat mass and hypothalamus, leading to dysregulated appetite and energy storage.
Why this rating
Well-established in the literature and cited by the paper.
Source
Obesity: a disease of the ponderostat and the regulation of energy balance
Silvio Buscemi et al. · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · 2025
DOI 10.1007/s40519-025-01790-9
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Preobese individuals with a low relative resting metabolic rate (RMR) normalized for fat-free mass are at higher risk for future weight gain and obesity.Good
- Obesity is a disease of the ponderostat characterized by a dysregulated neuroendocrine set point that actively defends a higher body weight through compensatory reductions in energy expenditure and increases in appetite.Moderate
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