Hormonal
Tirzepatide, a dual GLP-1/GIP receptor agonist, demonstrates significant efficacy in reducing body weight (over 20% in some cases) and improving glycemic control in patients with type 2 diabetes and obesity, suggesting therapeutic potential for women with Polycystic Ovary Syndrome (PCOS) who have comorbid obesity and insulin resistance.
For women with PCOS and obesity, tirzepatide offers a promising pharmacological tool to address both metabolic and reproductive symptoms. While not yet standard care for PCOS specifically, its ability to induce significant weight loss (>20%) and improve insulin sensitivity suggests it may help restore ovulation and reduce androgen levels. Treatment involves weekly subcutaneous injections starting at 2.5mg and titrating up to 15mg, ideally combined with lifestyle changes. Patients should be aware of potential GI side effects, though the drug's design aims to mitigate them.
tirzepatida... induz reduções ponderais superiores a 20% em casos de obesidade (JASTREBOFF ET AL., 2022), sugerindo seu potencial terapêutico também em mulheres com SOP.
Why this rating
The paper is a narrative review citing high-impact RCTs for general obesity/DM2, but explicitly states there are no specific clinical trials for PCOS yet.
Source
Potencial Aplicação da Tirzepatida no Manejo da Síndrome do Ovário Policístico: Uma Revisão Narrativa
Larissa Assumpção Gimenes de Souza et al. · RCMOS - Revista Científica Multidisciplinar O Saber · 2025
DOI 10.51473/rcmos.v1i2.2025.1548
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