Hormonal
Dual incretin agonists (e.g., Tirzepatide) reduce total body fat mass and adipocyte size more effectively than selective GLP-1 receptor agonists (e.g., Semaglutide, Dulaglutide) by modulating both GLP-1 and GIP receptors, leading to enhanced lipolysis and reduced visceral fat.
If you are considering a dual incretin agonist like Tirzepatide, be aware that it targets two hormonal pathways (GLP-1 and GIP) rather than just one. This dual action leads to a significantly greater reduction in total body fat and visceral fat compared to single-target GLP-1 drugs, offering a more potent option for weight management.
Tirzepatide is a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptors that has shown better glycemic control and greater weight loss compared to selective GLP-1RAs... Frías et al. noted that tirzepatide showed a significant reduction in body fat mass and adipocyte size... Compared to other anti-obesity medications (e.g., dulaglutide and semaglutide) administered over the same duration, tirzepatide demonstrated a superior reduction in body fat compartments, including total fat mass, VAT, and waist circumference
Why this rating
Based on a review of clinical trials and meta-analyses cited in the paper.
Source
Effects of GLP-1 receptor agonists and dual incretin agonists on adipocyte type and size
Nino Turashvili · Exploration of Endocrine and Metabolic Diseases · 2025
DOI 10.37349/eemd.2025.101452
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