Hormonal
Perioperative use of GLP-1 receptor agonists in obese patients undergoing total hip arthroplasty significantly reduces the incidence of periprosthetic joint infection and 90-day hospital readmissions.
If you are obese and scheduled for hip replacement, ask your surgeon about continuing or starting GLP-1 agonists (like semaglutide) up to 3 months before surgery. This may lower your risk of infection and hospital readmission without increasing other complications.
Perioperative GLP-1 therapy was associated with a significantly reduced incidence of PJI after total hip arthroplasty and fewer 90-day hospital readmissions, corresponding to an absolute risk reduction of approximately 1.8% from a median baseline risk of 9% and an estimated number needed to treat of 56.
Why this rating
Moderate certainty for THA-PJI and readmission based on observational cohorts with potential residual confounding.
Source
Reducing Periprosthetic Joint Infection in Patients With Obesity: A Systematic Review and Meta-Analysis of the Emerging Role of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists
André Daniel Aires Fernandes et al. · Cureus · 2025
DOI 10.7759/cureus.99805
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →