Research
Hormonal
Tirzepatide, a dual GIP/GLP-1 agonist, achieves greater weight loss (up to 22.5%) than GLP-1RAs alone, making it the most effective pharmacological weight loss therapy currently available.
If standard GLP-1 drugs aren't enough, ask your doctor about tirzepatide. It targets two hormones (GLP-1 and GIP) to help you lose more weight (up to 22.5%) than GLP-1 drugs alone. It is taken once weekly. Like other drugs in this class, it may cause digestive issues, but it is currently the most effective non-surgical medication for weight loss.
GoodSupportsHIGH confidence
Furthermore, tirzepatide is a dual agonist medication for both the GLP-1RA and the glucose-dependent insulinotropic polypeptide (GIP) receptor and has been shown in some studies to be more effective in weight loss, up to 22.5%, compared with GLP-1RAs [20].
Why this rating
Based on phase 3 trials (SURMOUNT-1) included in the review.
Source
Glucagon-Like Peptide-1 Receptor Agonists as a Non-surgical Alternative to Bariatric Surgery for Weight Loss: A Review
Chuh Steven et al. · Cureus · 2026
DOI 10.7759/cureus.100704
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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