Hormonal
Women with non-diabetic obesity experience greater cardiovascular benefits from GLP-1 RAs, particularly regarding heart failure hospitalization and stroke reduction, compared to men.
Women with obesity may derive even greater heart protection from GLP-1 medications than men, especially regarding heart failure prevention. This is particularly true for postmenopausal women who are at higher risk for heart failure with preserved ejection fraction (HFpEF). Discussing your specific heart failure risk with your provider is crucial.
Women (n=9,847, 63.8% of participants) demonstrated MACE reduction of 22% (RR 0.78, 95% CI 0.67-0.91, P=0.001)... However, women showed stronger heart failure hospitalization reduction (RR 0.73, 95% CI 0.58-0.92, P=0.008) compared to men (RR 0.94, 95% CI 0.75-1.18, P=0.59, P interaction=0.09)
Why this rating
Subgroup analysis of a high-quality meta-analysis; moderate quality evidence for HF hospitalization due to heterogeneity.
Source
Long-Term Cardiovascular Outcomes of Glucagon-Like Peptide-1 Receptor Agonists in Non-diabetic Obesity: A Systematic Review and Meta-Analysis
Kehinde Tom-Ayegunle et al. · Cureus · 2026
DOI 10.7759/cureus.100947
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