Research
Hormonal
State-of-the-art anti-obesity medications (AOMs) like GLP-1 analogues are highly effective appetite suppressants but require continuous use, as discontinuation leads to inevitable weight regain.
Understand that obesity medications like Semaglutide or Tirzepatide are long-term treatments. Stopping them will likely lead to weight regain. Plan for continuous use as part of your long-term health strategy.
LimitedQualifiesHIGH confidence
State-of-the-art AOMs are highly effective appetite suppressants with manageable side effects; however, they must be used continuously, as weight regain is otherwise inevitable.
Why this rating
Based on narrative review of multiple RCTs and guidelines.
Source
Pharmakologische und phytotherapeutische Strategien in der integrativen Adipositastherapie
Peter Panhofer et al. · Deutsche Zeitschrift für Akupunktur · 2026
DOI 10.1007/s42212-025-00797-8
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Phytotherapeutic agents (e.g., Green Tea, Nigella Sativa, Bofu Tsusho San) produce statistically significant but clinically less relevant weight loss compared to modern AOMs.Limited
- Tirzepatide (10-15 mg weekly) produces significantly greater total weight loss (-20.2%) compared to Semaglutide (1.7-2.4 mg weekly, -13.7%) in obese patients, as demonstrated in the SURMOUNT-5 trial.Weak
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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