Research
Hormonal
Rapid weight loss induced by semaglutide causes 'Ozempic Face' and 'Ozempic Butt' due to the skin's inability to shrink at the same rate as fat loss.
If you are using semaglutide, expect potential skin laxity, especially in the face and buttocks. Slower weight loss allows skin to adapt; rapid loss may result in sagging. Consider consulting a dermatologist for skin-tightening options if this is a major concern.
ModerateSupportsMEDIUM confidence
This is because Ozempic works by suppressing appetite and slowing gastric emptying, causing a large calorie deficit and rapid burning of fat reserves... Ozempic makes the weight fall faster so that the skin does not have time to adapt and loose skin occurs [36].
Why this rating
Based on observational reports and case studies cited in the review.
Source
A Shift from Diabetic Clinical Therapy to Aesthetic Use: The Ozempic Phenomenon
Nadya Theresia Sibarani et al. · Journal of Biosciences and Medicines · 2026
DOI 10.4236/jbm.2026.142019
narrative_review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Off-label use of semaglutide (Ozempic) for aesthetic weight loss in non-diabetic individuals causes therapeutic exclusion for Type 2 Diabetes patients due to supply shortages.Moderate
- Discontinuation of semaglutide leads to significant weight regain (rebound effect) and psychological distress due to the dissipation of hormonal effects.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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