Research
Hormonal
Semaglutide 2.4 mg once weekly is a highly effective treatment for obesity, leading to an average 14.9% body weight loss in nondiabetic adults over 68 weeks, and reduces major adverse cardiovascular events (MACE) in patients with obesity without diabetes.
Semaglutide 2.4 mg once weekly is a powerful treatment for obesity. In clinical trials, it helped people lose nearly 15% of their body weight. It also reduces the risk of major cardiovascular events in people with obesity but no diabetes. Discuss with your doctor if this once-weekly injection is right for you.
StrongSupportsVERY_HIGH confidence
Participants receiving semaglutide lost an average of 14.9% of body weight, compared with 2.4% in the placebo group over 68 weeks. This is also the only RCT in patients with obesity without diabetes that has shown a reduction in major adverse cardiovascular events (MACE) when an intentional weight loss strategy was used [88].
Why this rating
Supported by large-scale, double-blind, randomized controlled studies (STEP 1, SELECT).
Source
iCARDIO Alliance Global Implementation Guidelines for the Management of Obesity 2025
Stefan D. Anker et al. · Journal of Cachexia Sarcopenia and Muscle · 2026
clinical_guideline
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