Hormonal
Neutralization of the chemokine CXCL10 prevents high-fat diet-induced skeletal muscle atrophy and inflammation in mice.
This research suggests that in states of high metabolic stress (like high-fat diets), muscle loss is driven by specific inflammatory signals (CXCL10). While this is a mouse study, it implies that managing systemic inflammation might be as important as exercise for preserving muscle mass during weight loss or obesity.
neutralization of CXCL10 prevents HFD-induced muscle atrophy... CXCL10 mediates HFD-induced skeletal muscle atrophy by promoting inflammation and proteolysis.
Why this rating
Evidence is from murine models (C57BL/6J mice) and in vitro myotube cultures; not human clinical data.
Source
The role of <scp>CXCL10</scp> in high‐fat diet–induced skeletal muscle inflammation and atrophy
An Liyuan et al. · Journal of Diabetes Investigation · 2026
DOI 10.1111/jdi.70270
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