Research
Hormonal
Tirzepatide (all doses) provides statistically greater improvements in triglycerides and diastolic blood pressure compared to Liraglutide, and generally comparable improvements in other cardiometabolic parameters compared to Semaglutide.
Tirzepatide not only aids weight loss but also offers statistically greater improvements in triglycerides and diastolic blood pressure compared to Liraglutide, with generally comparable benefits to Semaglutide for other heart health markers.
GoodSupportsHIGH confidence
All tirzepatide doses were associated with statistically greater improvements in triglycerides and diastolic blood pressure versus liraglutide, and generally comparable improvements in other glycaemic, lipid and blood pressure parameters versus liraglutide and semaglutide.
Why this rating
Derived from the same NMA of RCTs.
Source
Comparison of Clinical Efficacy and Safety of Tirzepatide, Liraglutide and Semaglutide in Patients with Obesity and Without T2D: A Bayesian Network Meta-Analysis of Randomised Controlled Trials
Andreea Ciudin et al. · Advances in Therapy · 2026
DOI 10.1007/s12325-026-03523-5
Meta-analysis · 6 studies
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
Related findings · Hormonal
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