Hormonal
GLP-1/Apelin hybrid peptides enhance beta-cell proliferation and protect against cytokine-induced apoptosis, contributing to beta-cell survival.
These hybrid peptides show promise in protecting beta-cells from stress and promoting their growth in laboratory settings. This could translate to better long-term diabetes management by preserving the body's natural insulin production capacity.
These hybrid peptides also enhanced beta-cell proliferation and reduced cytokine-induced apoptosis.
Why this rating
Study is conducted in vitro (BRIN-BD11 cells) and ex vivo (isolated islets), not in humans.
Source
Unimolecular <scp>GLP</scp> ‐1/Apelin Hybrid Peptides Cause Prominent Appetite Suppression, as Well as Enhancing Insulin Secretion, Beta‐Cell Survival and Glycaemic Regulation
Ananyaa Sridhar et al. · Diabetes Obesity and Metabolism · 2026
DOI 10.1111/dom.70647
More from this paper
- Unimolecular GLP-1/Apelin hybrid peptides (specifically ELA, ELA-Lys12, and ELA-Lys38) cause prominent appetite suppression in mice without inducing malaise, with effects lasting up to 42 hours for the base peptide and 63 hours for acylated forms.Moderate
- GLP-1/Apelin hybrid peptides (ELA, ELA-Lys12, ELA-Lys38) significantly improve glucose tolerance and insulin secretion in both lean and high-fat-fed mice, with effects lasting up to 21 hours for acylated forms.Moderate
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