Research
Metabolic adaptation
Tirzepatide and semaglutide exceeded 10% total body weight loss and showed the most favorable glycaemic effects.
Tirzepatide and semaglutide may be prioritized for patients needing significant weight loss and glycaemic control.
StrongSupportsmedium confidence
Tirzepatide and semaglutide exceeded 10% TBWL and showed the most favourable glycaemic effects.
Why this rating
Based on the systematic review and meta-analysis of randomized controlled trials.
Source
A systematic review and meta-analysis of the efficacy and safety of pharmacological treatments for obesity in adults: 2026 Update
Andreea Ciudin Mihai et al. · medRxiv · 2026
DOI 10.64898/2026.04.19.26351196
Meta-analysisCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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