Research
Hormonal
Semaglutide, tirzepatide, and retatrutide achieve placebo-subtracted bodyweight loss of up to 10.8%, 17.8%, and 22.1%, respectively, in adults after 48-72 weeks.
These medications can significantly aid in weight loss for adults with obesity.
StrongSupportsmedium confidence
The most effective antiobesity drugs evaluated in double-blind, randomized controlled trials include semaglutide, tirzepatide, and retatrutide with up to 10.8%, 17.8%, and 22.1% placebo-subtracted bodyweight loss, respectively, in adults after 48-72 weeks.
Why this rating
Based on double-blind, randomized controlled trials.
Source
Antiobesity medications in adult and pediatric obesity and metabolic dysfunction–associated steatotic liver disease
Natalie Rodríguez et al. · Pharmacological Reviews · 2025
DOI 10.1016/j.pharmr.2025.100058
reviewCited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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