Research
Hormonal
Tirzepatide likely results in a greater percentage reduction in body weight from baseline (mean difference -16.03, 95% CI -18.91 to -13.14) compared to placebo.
Practitioners can consider tirzepatide as an effective option for weight loss in adults with obesity.
StrongSupportsmedium confidence
Tirzepatide likely results in a greater percentage reduction in body weight from baseline (mean difference (MD) -16.03, 95% confidence interval (CI) -18.91 to -13.14; 8 studies, 6317 participants; moderate-certainty evidence).
Why this rating
Based on meta-analysis of randomized controlled trials.
Source
Tirzepatide for adults living with obesity
Juan Víctor Ariel Franco et al. · Cochrane Database of Systematic Reviews · 2025
Meta-analysisCited 3×
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