Hormonal
Oral administration of the bis-lipidated GLP-1 receptor agonist MEDI7219 significantly reduces body weight and glucose excursions in a canine model of obesity and insulin resistance, demonstrating that peptide engineering and targeted delivery can overcome gastrointestinal barriers to achieve clinical efficacy.
This research validates a new class of oral GLP-1 drugs (like MEDI7219) that use specific engineering to survive digestion and absorb into the blood. In dogs, daily oral tablets successfully reduced weight and blood sugar. While human trials are not yet reported here, the mechanism suggests oral GLP-1s could eventually match injectables in efficacy while avoiding injections.
In a dog model of obesity and insulin resistance, MEDI7219 oral tablets significantly decreased food intake, body weight and glucose excursions, validating the approach.
Why this rating
High-quality preclinical data (dogs, multiple doses, clear metrics) but lacks human clinical trial results.
Source
Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease
Sergei Pechenov et al. · Scientific Reports · 2021
DOI 10.1038/s41598-021-01750-0
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