Hormonal
Exenatide once weekly improves glycemic control (A1C and FPG) and cardiovascular risk markers (SBP, LDL-C, triglycerides) independently of weight loss, although the magnitude of improvement is greater in patients with higher weight loss.
If you have Type 2 Diabetes, Exenatide once weekly will lower your blood sugar (A1C) and improve heart health markers even if you don't lose weight. However, you will get the biggest benefits if you do lose weight. Be aware that those who lose the most weight are more likely to experience nausea or hypoglycemia, especially if you are also taking sulfonylureas. Most people tolerate the injection well.
Exenatide once weekly improved glycemic parameters independent of weight change, although the magnitude of improvement increased with increasing weight loss.
Why this rating
Pooled analysis of 8 randomized controlled trials (N=1830) provides robust statistical power, though it is an observational analysis of pooled data rather than a single RCT.
Source
Association among weight change, glycemic control, and markers of cardiovascular risk with exenatide once weekly: a pooled analysis of patients with type 2 diabetes
Lawrence Blonde et al. · Cardiovascular Diabetology · 2015
DOI 10.1186/s12933-014-0171-2
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →