Hormonal
Higher circulating concentrations of fatty acids produced via de novo lipogenesis (specifically 16:0, 16:1n7, and 18:0) are positively associated with an increased incidence of type 2 diabetes.
High levels of certain fats produced by your body (de novo lipogenesis) from carbs and alcohol are linked to a higher risk of type 2 diabetes. This suggests that managing carbohydrate and alcohol intake may help regulate these specific internal fat pathways, potentially lowering diabetes risk, independent of overall body weight.
In pooled analyses, each of the fatty acids was positively associated with a higher risk of developing T2D. The associations were independent of major risk factors for T2D, such as age, sex, race/ethnicity, socioeconomic characteristics, smoking status, physical activity, and obesity.
Why this rating
Large-scale pooled prospective cohort analysis with harmonized methods, but observational design limits causal inference.
Source
Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: A pooled analysis of prospective cohort studies
Fumiaki Imamura et al. · PLoS Medicine · 2020
DOI 10.1371/journal.pmed.1003102
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