Research
Hormonal
GLP-1 RA use is associated with a higher risk of gallbladder or biliary diseases at higher doses (RR, 1.56; 95% CI, 1.36-1.78) compared to lower doses (RR, 0.99; 95% CI, 0.73-1.33).
Dosing strategies for GLP-1 RAs should consider the potential increased risk of gallbladder diseases.
StrongSupportsmedium confidence
Among all included trials, GLP-1 RA use was associated with higher risks of gallbladder or biliary diseases at higher doses (RR, 1.56; 95% CI, 1.36-1.78) compared with lower doses (RR, 0.99; 95% CI, 0.73-1.33).
Why this rating
Based on a systematic review and meta-analysis of randomized clinical trials.
Source
Association of Glucagon-Like Peptide-1 Receptor Agonist Use With Risk of Gallbladder and Biliary Diseases
Liyun He et al. · JAMA Internal Medicine · 2022
DOI 10.1001/jamainternmed.2022.0338
Meta-analysisCited 285×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Use of GLP-1 receptor agonists (GLP-1 RAs) is associated with an increased risk of gallbladder or biliary diseases (RR, 1.37; 95% CI, 1.23-1.52).Strong
- GLP-1 RA use is associated with increased risk of gallbladder or biliary diseases for longer durations (RR, 1.40; 95% CI, 1.26-1.56) compared to shorter durations (RR, 0.79; 95% CI, 0.48-1.31).Strong
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