Research
Hormonal
High intake of carbohydrates with a high glycemic index is associated with greater insulin resistance compared to low-glycemic-index carbohydrates.
Practitioners should consider recommending low-glycemic-index carbohydrates to improve insulin sensitivity.
StrongSupportsmedium confidence
In animals and in short-term human studies, a high intake of carbohydrates with a high glycemic index... produced greater insulin resistance than did the intake of low-glycemic-index carbohydrates.
Why this rating
Supported by animal and short-term human studies.
Source
Glycemic index, glycemic load, and risk of type 2 diabetes,,
Walter C. Willett et al. · American Journal of Clinical Nutrition · 2002
DOI 10.1093/ajcn/76/1.274s
reviewCited 267×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →