Research
Hormonal
1-year reinitiation was lower for those without type 2 diabetes (36.3%) compared with those with type 2 diabetes (47.3%).
Practitioners should note that patients without type 2 diabetes may have lower rates of reinitiating GLP-1 RA therapy.
StrongSupportsmedium confidence
1-year reinitiation was lower for those without type 2 diabetes (36.3% [95% CI, 35.6%-37.0%]) compared with those with type 2 diabetes (47.3% [95% CI, 46.6%-48.0%]).
Why this rating
Based on the large cohort study design.
Source
Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity
Patricia J. Rodriguez et al. · JAMA Network Open · 2025
DOI 10.1001/jamanetworkopen.2024.57349
cohort · n=125474Cited 236×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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