Hormonal
Genetically lower serum adiponectin levels cause increased insulin resistance, as evidenced by Mendelian randomization analysis of the ADIPOQ rs266729 polymorphism.
This study provides genetic evidence that low levels of the hormone adiponectin contribute directly to insulin resistance. While you cannot directly 'dose' adiponectin like a drug, this highlights the importance of lifestyle factors known to support healthy adiponectin levels, such as maintaining a healthy body weight and engaging in regular physical activity, as these may help mitigate insulin resistance through this hormonal pathway.
Our findings suggest a possible causal relation between a low serum adiponectin level and a higher level of insulin resistance.
Why this rating
Mendelian randomization provides strong causal inference, though the study sample size (N=1,157) is modest for detecting subtle genetic interactions.
Source
Causal Relationship between Adiponectin and Metabolic Traits: A Mendelian Randomization Study in a Multiethnic Population
Andrew Mente et al. · PLoS ONE · 2013
DOI 10.1371/journal.pone.0066808
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